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> participants who spent more than six hours working on a tedious and mentally taxing assignment had higher levels of glutamate โ€” an important signalling molecule in the brain. Too much glutamate can disrupt brain function, and a rest period could allow the brain to restore proper regulation of the molecule

https://www.nature.com/articles/d41586-022-02161-5 Why thinking hard makes us feel tired
 
 
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